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Project description :
The applicant will use bioinformatics and functional genomics to characterize primary transcriptional targets of nuclear receptors on a genomic scale and analyze the tissue specificity of gene networks controlled by these receptors.
Qualifications :
Applicants with a Ph.D.. or equivalent degree and previous experience in the field of transcriptional regulation and/or bioinformatics will be prioritized. Functional knowledge of English (spoken and written) is required.
Starting date : end 2004 - begining 2005
Contact Information :
Dr Mader
Département de Biochimie,
Université de Montréal
CP 6128 Succursale Centre Ville
MONTREAL QC H3C 3J7
Phone: 514-343-6111 #5173
Fax:514-343-2210
Email:sylvie.mader@umontreal.ca
Home page:Sylvie Mader
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Project description :
The applicant will participate in an ongoing research program aiming at a better understanding of the molecular determinants of the partial versus total antagonist activity of antiestrogens, and of the functional consequences of their interaction with estrogen receptors.
Qualifications :
Applicants with an M.Sc. or equivalent degree and previous experience in the structure/function analysis of proteins will be prioritized. Applicants will be expected to join a Ph.D. program either at Université de Montréal (Dept of Biochemistry) or at McGill University (Dept of Medicine). Functional knowledge of English or French (spoken and written) is required.
Starting date : end 2004 - begining 2005
Contact Information :
Dr Mader
Département de Biochimie,
Université de Montréal
CP 6128 Succursale Centre Ville
MONTREAL QC H3C 3J7
Phone: 514-343-6111 #5173
Fax:514-343-2210
Email:sylvie.mader@umontreal.ca
Home page:Sylvie Mader
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Project description :
The applicant will conduct experiments using both cellular and animal models for tumor cell growth and glucose metabolism. The effect of glucose deprivation and glycolysis inhibition on proliferation of tumor cells will be investigated under both normoxic and hypoxic conditions. Drug tolerance will be assessed in mouse models, and the effect of inhibitors on tumor growth will be monitored. This project will be conducted under the joint supervision of Drs J. Sygusch and Dr. S. Mader.
Qualifications :
Applicants with an M. Sc. degree and experience in tissue culture and animal handling will be prioritized. Functional knowledge of English or French is required.
Starting date : autumn 2004
Contact Information :
Dr Sygusch and/or Dr Mader
Département de Biochimie,
Université de Montréal
CP 6128 Succursale Centre Ville
MONTREAL QC H3C 3J7
Phone: 514-343-6111 #5173
Fax:514-343-2210
Email:sylvie.mader@umontreal.ca
Home page:Sylvie Mader
Phone: (514) 343-2389
Fax:(514) 343-6463
Email:Jurgen.Sygusch@UMontreal.CA
