Our research is oriented to provide a molecular-level understanding of chemical reactivity in complex environments to enable construction and application of molecular architectures having nanometer-sized dimensions. This multidisciplinary research effort employs novel chemical and biochemical approaches to design functional molecular, supramolecular, and self-organized systems. Our endeavours span the areas of synthetic organic chemistry, physical organic chemistry, bioorganic chemistry, biophysics, enzymology and molecular biology.
PUBLICATIONS
We described the use of the ortho-nitrophenyl-β-galactoside (ONPG) assay developed by Lehrer et al. to which a new mathematical data treatment was applied. This assays is a valuable tool to monitor membrane permeabilization and destabilization.
We develop ligands and study their respective metal assemblies in phospholipid membranes. Anion transport experiments demonstrate the formation of metal–organic synthetic transporters (MOST) directly in phospholipid membranes.
We study the catalytic activity of an in situ generated palladium(II)/biguanides complexes in neat water for the Suzuki–Miyaura and Sonogashira cross-coupling reactions.
This methodology showcased recyclability of tcross-coupling reactions, performed with small palladium loading.
We exploit the toxicity of imidazolium and benzimidazolium salts in the development of different biological applications by incorporating them in the structure of compounds that specifically target microorganisms and cancereous cells.
Investigation of classical organic and ionic liquid co-solvents for early stage screening in fragment-based inhibitor design with unrelated bacterial and human dihydrofolate reductases.
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Latest News
Welcome to the new students!
We have the pleasure to welcome our MSc Samy Faraj and Maude Petit and Sigrid Lacaille as PhD students! Welcome in our group!
Andreea is nominated as Fellow of the Royal Society of Chemistry (UK) and appointed as member of the Editorial board of the journal "Supramolecular chemistry" and Canadian Journal of Chemistry!
Defenses
Jérémie Tessier defended his PhD in August 2020 becoming the first Covid-19 Doctor!